THE EFFICACY OF LOW-DOSE ENOXAPARIN IN PSORIASIS

Psoriasis is a frequently encountered inflammatory skin disease with unclear etiology and no curative therapy. Enoxaparin low-molecular weight heparin analogue. Heparin its analogues in low doses have antiproliferative immunomodulatory effects. Low-dose enoxaparin has inhibitory effects on T cell-mediated immune reactions. lymphocytes play key role the immunpathogenesis of psoriasis. The aim this study was to evaluate efficacy low-dose treatment Twenty-three patients chronic plaque guttate psoriasis were enrolled an open study. Patients given subcutaneous injections 5 mg once weekly for total 6 weeks. There statistically significant difference between PASI (Psoriasis Area Severity Index) scores at beginning 6th week follow up (p=0.008). Four out 23 (17%) showed marked improvement (≥50% reduction score), eight (35%) moderate (25-49% reduction), five (22%) unchanged (